Site-selective 18F fluorination of unactivated C–H bonds mediated by a manganese porphyrin
نویسندگان
چکیده
منابع مشابه
Oxidative aliphatic C-H fluorination with fluoride ion catalyzed by a manganese porphyrin.
Despite the growing importance of fluorinated organic compounds in drug development, there are no direct protocols for the fluorination of aliphatic C-H bonds using conveniently handled fluoride salts. We have discovered that a manganese porphyrin complex catalyzes alkyl fluorination by fluoride ion under mild conditions in conjunction with stoichiometric oxidation by iodosylbenzene. Simple alk...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2018
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c7sc04545j